Fulfilling the promise of Mendelian randomization
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منابع مشابه
Emerging Themes in Epidemiology Analytic perspective Can we apply the Mendelian randomization methodology without considering epigenetic effects?
Introduction: Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks. Similarly, Mendelian randomization studies, which use the IV methodology for analysis and inference in epidemiology, were introduced into the epidemiologist's toolbox only in the last decade. Analysis: Mendeli...
متن کاملCan we apply the Mendelian randomization methodology without considering epigenetic effects?
INTRODUCTION Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks. Similarly, Mendelian randomization studies, which use the IV methodology for analysis and inference in epidemiology, were introduced into the epidemiologist's toolbox only in the last decade. ANALYSIS Mendeli...
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1. Davey Smith G, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1–22. 2. Burgess S, Timpson NJ, Ebrahim S, Davey Smith G. Mendelian randomization: where are we now and where are we going? Int J Epidemiol 2015;44:379–88. 3. Glymour MM, Tchetgen EJT, Robins JM. Credible Mendelian randomizat...
متن کاملAuthors’ response to Hartwig and Davies
1. Davey Smith G, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1–22. 2. Burgess S, Timpson NJ, Ebrahim S, Davey Smith G. Mendelian randomization: where are we now and where are we going? Int J Epidemiol 2015;44:379–88. 3. Haycock PC, Burgess S, Wade KH, Bowden J, Relton C, Davey Smith G....
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Mendelian randomization investigations are becoming more powerful and simpler to perform, due to the increasing size and coverage of genome-wide association studies and the increasing availability of summarized data on genetic associations with risk factors and disease outcomes. However, when using multiple genetic variants from different gene regions in a Mendelian randomization analysis, it i...
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